Slavov Lab | Welcome new members

This welcome page outlines the goals and the logistical organization of the Slavov Laboratory. It also provides links to accessible introductory resources for scientific topics and technologies relevant to our research.

Goals

Help each lab member to grow as a scientist / engineer and become more independent
Learn to prioritize, to focus on the essential and ignore distractions
Learn to formulate and test hypotheses
Develop new skills
Make discoveries and develop methods that are conceptually original, distinctive & non-redundant.
Publish papers, advance our careers and raise support for the goals above.

Organization

Scheduling
- All scheduling is done via the lab google calendar that will be shared with you.
Data Sharing & Communication
- We also communicate via lab slack account: https://slavovlab.slack.com/
- Announcement to the entire group are sent via the group email: quantlab@listserv.neu.edu
- We share data and collaborate on manuscripts via google drive, overleaf, and google docs
- The slides for all lab presentations have to be placed in the designated google drive folder.
- We have a business lab google account for data storage for mass spec data. It is research@slavovlab.net

Meetings

Weekly group meeting
- Summarize results from the last 1-2 months or lead a journal club discussion. The goal is to present your results more holisticaly in perspective. We rotate alphabetically according the order from our website.
- Get feedback from everybody and practice your presention skills.
Weekly club meetings
- Design experiments, set goals, get help with data analysis and interpretation
- Present less mature results to colleagues who need little background
- Update on goals set the previous week / month.
- To stay focused and organized, we follow Focus 20/20:
  - Start with the central point / goal of the presented work
  - Presenations are up to 20 min max.
General Meeting Time (GMT)
- Questions of limited interest for the rest of the group
- Detailed feedback on manuscripts, career development, et al.
- If you want a 1-1 meeting, book a slot within the GMT period.

The meetings do not have to take the full allotted time.

Introductory resources

Mass spectrometry

Videos
- Introduction to mass spectrometry experiments and their optimization by Gray Huffman
- A basic into to proteomic identification through database search by David Tabb
- Introduction to mass spectrometry by Harrison Specht
- Introduction to mass spectrometry by Nikolai Slavov
- Primer on single-cell proteomics by mass spectrometry by Nikolai Slavov
- Biological and technological frontiers for single-cell proteomics
Review Articles
- Computational methods for understanding mass spec data: Sinitcyn, Cox et al., 2018
- Protein Analysis by mass spec [small book]: Yates et al., 2013
- Single-cell protein analysis by mass spectrometry: Slavov, 2020
Perspective Articles
- Framework for multiplicative scaling of single-cell proteomics, Nature Biotechnol
- Advancing single-cell proteomics, JPR Perspective
- Single-cell proteomics, Science Perspective
Courses: Lectures and problems from past courses are available from our teaching pages.

Regulation of protein synthsis and degradation

Videos
- Alternative translation
- Differential stoichiometry among core ribosomal proteins
Review Papers


	Slavov Laboratory \| Quantitative Biology Seeking principles in the coordination among protein synthesis, metabolism, cell growth and differentiation
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Welcome
This welcome page outlines the goals and the logistical organization of the Slavov Laboratory. It also provides links to accessible introductory resources for scientific topics and technologies relevant to our research. Goals Help each lab member to grow as a scientist / engineer and become more independent Learn to prioritize, to focus on the essential and ignore distractions Learn to formulate and test hypotheses Develop new skills Make discoveries and develop methods that are conceptually original, distinctive & non-redundant. Publish papers, advance our careers and raise support for the goals above. Organization Scheduling All scheduling is done via the lab google calendar that will be shared with you. Data Sharing & Communication We also communicate via lab slack account: https://slavovlab.slack.com/ Announcement to the entire group are sent via the group email: quantlab@listserv.neu.edu We share data and collaborate on manuscripts via google drive, overleaf, and google docs The slides for all lab presentations have to be placed in the designated google drive folder. We have a business lab google account for data storage for mass spec data. It is research@slavovlab.net Meetings Weekly group meeting Summarize results from the last 1-2 months or lead a journal club discussion. The goal is to present your results more holisticaly in perspective. We rotate alphabetically according the order from our website. Get feedback from everybody and practice your presention skills. Weekly club meetings Design experiments, set goals, get help with data analysis and interpretation Present less mature results to colleagues who need little background Update on goals set the previous week / month. To stay focused and organized, we follow Focus 20/20: Start with the central point / goal of the presented work Presenations are up to 20 min max. General Meeting Time (GMT) Questions of limited interest for the rest of the group Detailed feedback on manuscripts, career development, et al. If you want a 1-1 meeting, book a slot within the GMT period. The meetings do not have to take the full allotted time. Introductory resources Mass spectrometry Videos Introduction to mass spectrometry experiments and their optimization by Gray Huffman A basic into to proteomic identification through database search by David Tabb Introduction to mass spectrometry by Harrison Specht Introduction to mass spectrometry by Nikolai Slavov Primer on single-cell proteomics by mass spectrometry by Nikolai Slavov Biological and technological frontiers for single-cell proteomics Review Articles Computational methods for understanding mass spec data: Sinitcyn, Cox et al., 2018 Protein Analysis by mass spec [small book]: Yates et al., 2013 Single-cell protein analysis by mass spectrometry: Slavov, 2020 Perspective Articles Framework for multiplicative scaling of single-cell proteomics, Nature Biotechnol Advancing single-cell proteomics, JPR Perspective Single-cell proteomics, Science Perspective Courses: Lectures and problems from past courses are available from our teaching pages. Regulation of protein synthsis and degradation Videos Alternative translation Differential stoichiometry among core ribosomal proteins Review Papers Ribosome Stoichiometry: From Form to Function (Emmott Jovanovic & Slavov, 2018)

Copyright © Nikolai Slavov