Seeking principles
in the coordination among protein synthesis, metabolism, cell growth and differentiation
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Single-cell proteomics
Single-Cell ProtEomics by Mass-Spec: SCoPE-MS, SCoPE2, pSCoPE, plexDIA Quantifying proteins, their modifications, and dynamics in single cells with mass spectrometry Protein Synthesis & Degradation
Alternate RNA decoding results in stable and abundant proteins in mammals Direct evidence for differential stichiometry of ribosomal proteins The stoichiometry among ribosomal proteins (RP) correlates to the growth rate The RP stoichiometry depends on the growth conditions Metabolism & Aerobic Glycolysis
We found that exponential growth at a constant rate can represent not a single metabolic/physiological state but a continuum of changing states and that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival. Increasing stress sensitivity and aerobic glycolysis during exponential growth Parallel declines in respiration and in mitochondrial NADPH-producing enzymes Global remodeling of metabolism during nine doublings at a constant rate Cell Growth & Division
We found that most genes annotated to the cell division cycle are expressed periodically even in nondividing cells as part of a cell growth cycle Connecting single-cell gene-expression dynamics to population-average gene-expression Statistical Inference
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