Slavov Laboratory | Quantitative Biology

Supporting Information

Constant Growth Rate Can Be Supported by Decreasing Energy Flux and Increasing Aerobic Glycolysis

Summary

We found that exponential growth at a constant growth rate represents not a single metabolic/physiological state but a continuum of changing states characterized by different oxidative- and heat-stress resistance, protein expression and metabolic fluxes. Metabolic fluxes that change during exponential growth include respiration, fermentation, and folate-mediated NADPH production.

Warburg Effect during Exponential growth at a Constant Rate

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Cell Density Growth Curve
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